MSCA Doctoral Network PhD position: Structure-based design of novel peptide-derived β-catenin inhibitors

This PhD position is part of the MSCA Doctoral Network at Georg August University Göttingen, focusing on the design of novel peptide-derived β-catenin inhibitors. The research involves identifying key binding regions in peptides and developing peptidomimetics to inhibit Wnt signaling. Candidates will engage in solid-phase peptide synthesis, fluorescence polarization assays, and protein X-ray crystallography. The role requires a strong background in peptide synthesis and biochemical assays, with the opportunity to contribute to significant advancements in cancer treatment.

• Conduct research on peptide-derived β-catenin inhibitors.
• Perform solid-phase synthesis of peptides.
• Utilize fluorescence polarization assays to identify binding regions.
• Characterize interactions between peptides and β-catenin.
• Engage in structural elucidation using X-ray crystallography.
• Test modified peptides in cell-based assays for Wnt signaling inhibition.
• Collaborate with team members and contribute to project goals.