PhD in Computational Systems Biology / Bioinformatics

This PhD position is hosted by the Centre for Integrative Biology (CBI) in Toulouse, France, as part of the MSCA PANDORA doctoral network investigating age-related macular degeneration (AMD). The successful candidate will design large-scale molecular interaction maps, convert them into executable Boolean models, and integrate them into agent-based multi-scale models to build a retinal digital twin. The project aims to simulate pathological mechanisms and test therapeutic strategies in silico under the supervision of Professor Anna Niarakis. Applicants are expected to hold a Master's degree and bring strong computational biology skills to advance predictive modeling for retinal disease.

• Construct large-scale molecular interaction maps of retinal mechanisms and complement system pathways linked to age-related macular degeneration.
• Convert molecular interaction maps into executable Boolean models utilizing established frameworks.
• Adapt and calibrate computational models using experimental omics data generated within the PANDORA consortium.
• Integrate Boolean models into agent-based multi-scale frameworks to simulate intercellular communication and tissue homeostasis.
• Perform in silico experiments to evaluate environmental stress, extracellular matrix variations, and genetic perturbations.
• Compare computational predictions with in vitro data provided by project collaborators for model validation.
• Identify and prioritize novel therapeutic targets for AMD to support experimental drug validation strategies.