Doctoral Researcher in β-Catenin Ligands & Cell Differentiation

Join a cutting-edge PhD project focused on Wnt/β-catenin signaling.

Best for:Ideal for candidates with a strong foundation in biochemistry and cell biology, eager to engage in innovative research.

University of Luxembourg · Esch-sur-Alzette, Luxembourg · R1 · First-stage researcher

More professors at University of Luxembourg

Cancer ResearchMolecular BiologyCell BiologyDevelopmental BiologyBiochemistryBiophysics

Deadline

N/A

Funding

—

Start date

flexible

Full-time

Location

Esch-sur-Alzette

Luxembourg

Overview

The University of Luxembourg is seeking a Doctoral Researcher to explore the role of β-catenin in cell differentiation. This position involves developing BRET biosensors to study intracellular interactions and the effects of peptidic ligands on C2C12 cells. The researcher will engage in hands-on experimental work, contributing to a multidisciplinary team within the FlexCAT programme. Candidates should be motivated for international research and possess a strong background in relevant biological sciences.

β-cateninWnt signalingcell differentiationBRET biosensorsC2C12 cellspeptidic ligandsmolecular biochemistryfluorescence microscopy

What you'll do

Assess the impact of Wnt signaling on C2C12 progenitor cells and their differentiation.
Create specialized BRET biosensors to analyze protein-protein interactions within the Wnt pathway.
Examine how peptidic ligands influence Wnt/β-catenin signaling and differentiation.
Conduct measurements of cellular differentiation, signaling responses, and β-catenin localization.
Develop BRET biosensors for monitoring target engagement and molecular events.
Integrate cellular data with ligand optimization efforts in the FlexCAT programme.

Requirements

Degree required: MSc in Biochemistry, Developmental Biology, Biophysical Chemistry or a related field

Degree offered: PhD

Language: English; excellent proficiency required

Instruction: English

Required skills

Strong knowledge of molecular biochemistry and cell biology techniques.
Experience with fluorescence microscopy and/or bioluminescence experiments.
Basic skills in cell culture and familiarity with cellular differentiation models.
Excellent project management and communication abilities.

Nice to have

Experience in multidisciplinary research environments.Motivation for hands-on experimental work and participation in conferences.

Eligibility

Must comply with MSCA mobility rule: no more than 12 months of residence in Luxembourg in the last 36 months.

Funding & terms

Type

Unknown

Amount

—

Duration

—

Programme

MSCA remuneration package

How to apply

Deadline: N/A

Applications must be submitted exclusively through the FlexCAT Recruitment Portal. Follow the steps to select the project and complete your application online.

Documents required

CV
Cover letter
Transcripts
Proof of language proficiency

↗Apply on site

Lab

Faculty of Science, Technology and Medicine

University of Luxembourg

MSCA remuneration packageLuxembourg

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