PhD Position in Molecular Mechanisms of Neurodegenerative Diseases

The International PhD Programme (IPP) in Mainz, Germany, invites talented life science graduates to apply for a fully funded doctoral position at the Institute of Molecular Biology. Working within the research group of Dorothee Dormann, the successful candidate will explore the molecular mechanisms by which neurodegeneration-linked RNA-binding proteins FUS and TDP-43 contribute to R-loop suppression and DNA repair. The project utilizes a combination of in vitro assays, cellular model systems, advanced fluorescence microscopy, and proximity proteomics. The researcher will benefit from state-of-the-art core facilities, comprehensive professional training, and an active international scientific community.

• Investigate the molecular mechanisms by which FUS and TDP-43 contribute to R-loop suppression and DNA repair using in vitro and cellular model systems.
• Examine how the protein interactome of FUS and TDP-43 is altered upon DNA damage using proximity proteomics.
• Analyze the phase separation and condensation behavior of FUS and TDP-43 in relation to DNA/RNA binding and damage site recruitment.
• Study the impact of post-translational modifications such as ADP-ribosylation and phosphorylation on R-loop regulation.
• Perform genome-wide R-loop mapping and advanced fluorescence microscopy or live-cell imaging.
• Collaborate within the RTG on R-loop Regulation in Robustness and Resilience (4R) consortium and present findings at internal and external meetings.