AI/ML Postdoctoral Fellow

The Francis Crick Institute invites applications for a four-year Postdoctoral Fellow to join the Tissue Regeneration and Clonal Evolution (TRCE) Laboratory. Working in close collaboration with the Wellcome Sanger Institute and the Lotfollahi Lab, the successful candidate will develop and apply cutting-edge machine learning methods to large-scale spatial genomics and multi-modal biological datasets. The role focuses on investigating how driver mutation clones interact with their microenvironment in chronic liver disease and cancer. The researcher will be embedded across both institutes and is expected to drive high-impact computational research, collaborate with interdisciplinary teams, and lead manuscript preparation.

• Develop advanced AI and machine learning methods for analyzing spatial genomics and histology datasets.
• Apply graph neural networks, transformer models, and generative AI approaches to investigate clone-microenvironment interactions.
• Integrate spatial transcriptomics, single-cell sequencing, and imaging datasets into unified workflows.
• Design robust benchmarking strategies and reproducible computational pipelines.
• Perform clonal reconstruction and spatial mapping analyses from complex genomic datasets.
• Collaborate closely with computational scientists, clinicians, and experimental researchers across multiple research institutes.
• Lead publications, conference presentations, and the broad dissemination of research findings.