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Biochemistry● Open★ MSCAPreview

MSCA Doctoral Network PhD position: Deciphering the molecular grammar of β-catenin/IDR interactions

Join a pioneering project to explore β-catenin interactions in biochemistry.

Best for:Best for candidates with a strong foundation in biochemistry and a passion for molecular biology.

Technical University of Vienna · Graz, Austria · R1 · First-stage researcher
More professors at Technical University of Vienna
β-cateninintrinsically disordered proteinsprotein-protein interactionstranscriptional regulation
Deadline
Oct 31, 2026
17 days
Funding
Salaried
Competitive salary comprising a Living Allowance, Mobility Allowance, and Family Allowance if applicable
Start date
January 2027 – March 2027
Full-time
Location
Graz
Austria

Overview

This PhD position focuses on understanding the molecular interactions between β-catenin and intrinsically disordered regions (IDRs). Conducted at the Medical University of Graz, the project aims to elucidate how these interactions are regulated and their implications for transcriptional regulation. The candidate will work within a collaborative doctoral network, leveraging expertise in structural biology and biochemistry. Applicants should be motivated and possess a strong background in relevant scientific fields.

PhDbiochemistrymolecular biologystructural biologyprotein interactionsNMR spectroscopyhigh-throughput screeningmass spectrometry

What you'll do

  • Characterize the interaction and structure of IDRs that bind to β-catenin.
  • Investigate how phosphorylation affects β-catenin and IDR interactions.
  • Explore the role of β-catenin in IDR-mediated condensate formation.
  • Conduct high-throughput screening and other quantitative interaction studies.
  • Collaborate with various research groups within the doctoral network.
  • Engage in international secondments to enhance research experience.

Requirements

Degree required: Master's degree in Biochemistry, Molecular Biology, Structural Biology, or a related field

Degree offered: PhD

Language: English; Excellent proficiency required

Instruction: English

Required skills
  • Strong background in biochemistry and molecular biology
  • Experience in recombinant protein expression and purification
  • Familiarity with biochemical and biophysical characterization techniques
  • Analytical skills and enthusiasm for interdisciplinary research
Nice to have
Experience with NMR spectroscopy or structural biology methodsKnowledge of protein post-translational modificationsFamiliarity with X-ray crystallography and mass spectrometry
Eligibility
  • Open to candidates with a Master's degree or equivalent
  • 1-4 years of research experience preferred

Funding & terms

Type
Salaried
Amount
Competitive salary comprising a Living Allowance, Mobility Allowance, and Family Allowance if applicable
Duration
3 years
Programme
Horizon Europe - MSCA
EU-FUNDEDHorizon Europe

How to apply

Deadline: 2026-10-31 (Europe/Vienna)

Applications must be submitted through the Recruitment Portal. Required documents include a motivation statement, detailed CV, academic transcripts, and contact details for two referees.

Documents required
  • Motivation statement
  • Detailed CV
  • BSc/MSc diplomas and academic transcripts
  • Contact details for two referees
↗Apply on site

Contact

AC
Prof.
Anne Conibear
Medical University of Graz
Lab
Madl group
Technical University of Vienna
Horizon Europe - MSCAAustria
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