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Biomedicine● OpenResearch staffPreview

CryoEM Staff Scientist

Operate, maintain, and advance high-end cryo-electron microscopy facilities supporting structural and cell biology research.

Best for:Best for experienced microscopists with a PhD in a related field, strong hardware and scripting skills, and a passion for collaborative structural biology.

Howard Hughes Medical Institute (HHMI) · Ashburn, United States · R2 · Recognised researcher
More professors at Howard Hughes Medical Institute (HHMI)
Cryo-Electron MicroscopyStructural BiologyCell BiologyMicroscopy HardwareImage Processing
This is a research staff position — not a PhD studentship.
Deadline
Dec 13, 2026
58 days
Funding
Salaried
$97.1k–$157.8k/yr
Start date
flexible
Permanent
Location
Ashburn
United States

Overview

The Howard Hughes Medical Institute (HHMI) Janelia Research Campus seeks a CryoEM Staff Scientist to manage and operate advanced electron microscopes within its shared resource facility. The role involves collecting high-throughput data, collaborating with internal research teams on complex structural and cell biology projects, and developing novel sample preparation and imaging protocols. The successful candidate will act as a scientific peer and technical expert, troubleshooting advanced hardware and mentoring facility users. This on-site position offers a competitive compensation and benefits package in Ashburn, Virginia.

CryoEMTitan KriosFIBSEMMicroscopyStaff ScientistStructural BiologyJanelia

What you'll do

  • Operate and maintain end-to-end cryoEM equipment including Titan Krios microscopes and sample preparation systems.
  • Troubleshoot complex hardware and software issues directly in coordination with vendor engineers and research peers.
  • Take a leading role in the cryoEM aspects of collaborative research projects from experimental design to data interpretation.
  • Develop, implement, and optimize new protocols for sample preparation, high-throughput data collection, and image processing.
  • Train facility users and new staff members on advanced cryoEM methods, instrumentation, and standard operating workflows.
  • Manage biological samples, cryogen supplies, and data transfers securely and meticulously.

Requirements

Degree required: PhD in a related scientific field

Language: English

Instruction: English

Required skills
  • Extensive experience operating sophisticated electron microscopy hardware
  • Proficiency in Linux, bash scripting, and basic Python for system troubleshooting
  • Ability to manage multiple concurrent user projects under strict operational timelines
  • Demonstrated aptitude for teaching and mentoring researchers on technical methodologies
Nice to have
Hands-on expertise with cryoEM sample preparation and image processing softwareBackground in 4D scanning transmission electron microscopy (4D STEM)

Funding & terms

Type
Salaried
Amount
$97.1k–$157.8k/yr
Duration
—
Programme
Howard Hughes Medical Institute (HHMI)
Howard Hughes Medical Institute (HHMI)

How to apply

Deadline: 2026-12-13

Submit your application online through the official careers portal by the specified deadline. Ensure all required application documents are attached as requested in the posting.

Documents required
  • CV
  • Cover letter
↗Apply on site
Lab
Janelia Research Campus
Howard Hughes Medical Institute (HHMI)
United States
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