PhD Position in Colorectal Cancer and BAF-Associated ARID Proteins
Investigate the role of BAF-associated ARID proteins in DNA mismatch repair and cell cycle control within colorectal cancer models.
Best for:Best for ambitious life sciences graduates with a background in molecular biology, genomics, or cancer research and an interest in chromatin remodeling.
Overview
The International PhD Programme (IPP) at the Institute of Molecular Biology in Mainz, Germany, is offering a fully funded doctoral position within the research group of Sandra Schick. The successful candidate will investigate how BAF complex ARID subunit mutations drive colorectal cancer through effects on DNA mismatch repair and cell cycle regulation. Working in an interdisciplinary and international environment, the researcher will employ cutting-edge techniques including CRISPR genome editing, single-cell NGS, proteomics, and colon organoid cultures in collaboration with the Luck lab. Applicants are expected to hold a relevant master's degree and demonstrate a strong interest in molecular oncology and functional genomics.
What you'll do
- Design and execute experiments using CRISPR-engineered cancer cell lines and colon organoid cultures
- Apply bulk and single-cell next-generation sequencing (NGS) along with proteomics techniques
- Perform compound screening assays to evaluate therapeutic vulnerabilities linked to ARID mutations
- Analyze the impact of ARID subunit loss on microsatellite instability and DNA mismatch repair
- Investigate cell cycle regulation mechanisms in an ARID-dependent manner
- Collaborate closely with structural proteomics researchers in the Luck lab
- Present scientific findings at internal meetings and international conferences
Requirements
Degree required: Master Degree or equivalent in Life Sciences or related field
Degree offered: PhD
Language: English; good command required
Instruction: English
- Master degree or equivalent in a relevant scientific discipline
- Interactive personality with strong collaborative skills
- Proficiency in molecular biology or cell culture techniques
- Hold a Master degree or equivalent by the start of employment
Funding & terms
How to apply
Deadline: 2026-10-15 (Europe/Berlin)
Interested applicants must apply through the online application platform provided by the International PhD Programme. Candidates should select the Schick (BAF) group preference within the application portal and submit all required documentation before the deadline.
- CV
- 2 letters of reference
Contact
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