PhD position: Targeted Radioenhancing Nanoparticles for Neuroblastoma
Develop intravenous hafnium oxide nanoparticles to improve radiotherapy efficacy for high-risk pediatric neuroblastoma.
Best for:Best for candidates with a background in Chemistry or Biochemistry and an interest in nanomedicine and cancer research.
Overview
This PhD project focuses on the development of ultrasmall, intravenously deliverable hafnium oxide nanoparticles designed to enhance radiotherapy for high-risk neuroblastoma. By improving the targeting and circulation of these radioenhancers, the research aims to increase local tumor damage while minimizing toxicity to healthy tissues. The successful candidate will work at the intersection of nanochemistry and translational cancer research, utilizing neuroblastoma organoids and 3D models for preclinical evaluation. The position is hosted by the University of Basel and provides membership in the Swiss Nanoscience Institute (SNI) PhD school. Applicants are expected to contribute to a next-generation strategy for making radiotherapy more effective and accessible for pediatric patients.
What you'll do
- Design and synthesize ultrasmall hafnium oxide nanoparticles for intravenous delivery.
- Optimize nanoparticle surface chemistry to improve circulation and tumor targeting.
- Evaluate therapeutic performance of nanoparticles in neuroblastoma organoid models.
- Conduct preclinical research using physiologically relevant 3D tumor models.
- Collaborate with interdisciplinary research groups within the Swiss Nanoscience Institute.
- Contribute to the development of novel strategies for selective radiotherapy.
Requirements
Degree required: Master's degree in Chemistry or Biochemistry
Degree offered: PhD
Language: English proficiency required.
Instruction: English
- Strong academic background in Chemistry or Biochemistry.
- Experience with nanoparticle synthesis or surface chemistry.
- Experience with biochemical or biological research methods.
- Proficiency in written and spoken English.
Funding & terms
How to apply
Deadline: 2026-10-15 (Europe/Zurich)
Applications must be submitted through the official online platform provided by the Swiss Nanoscience Institute. Ensure all required documentation is uploaded before the deadline. For specific inquiries, contact the head of the PhD programme or the project leaders directly.
- CV
- Academic transcripts
- Cover letter
Contact
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