PhD Studentship: The Role of SNORD116 in Adipocyte Metabolic Development

This PhD studentship at the University of East Anglia offers an exciting opportunity to investigate the role of small nucleolar RNAs (snoRNAs), specifically SNORD116, in regulating the metabolic development of adipocytes. Based in the Smith Lab at Norwich Medical School, the project employs state-of-the-art gene-edited pluripotent stem cells to uncover novel insights into RNA biology and metabolic health. The successful candidate will receive comprehensive training in advanced techniques such as stem cell biology, single-cell sorting, metabolomics, and long-read RNA sequencing. Applicants are expected to engage actively in independent research while benefiting from high-quality instruction in broader scientific and transferable skills.

• Culture and manipulate gene-edited pluripotent stem cells for directed differentiation studies
• Examine the regulatory mechanisms of snoRNAs in adipocyte metabolism using advanced cellular assays
• Perform advanced flow cytometry and single-cell sorting experiments
• Generate and analyze long-read RNA sequencing and metabolomics datasets
• Participate in laboratory meetings, departmental seminars, and professional development training