MSCA Doctoral Network PhD position: Generation and Screening of Chemically Diverse Cyclic Peptide Libraries

This PhD position focuses on the development and screening of cyclic peptide libraries to enhance drug discovery processes. The project, part of the Horizon Europe MSCA-DN initiative, aims to optimize β-catenin binders through innovative microarray techniques. Candidates will engage in peptide synthesis, library evaluation, and biophysical characterization, contributing to advancements in pharmacological properties. Successful applicants will collaborate with leading researchers and gain valuable training in high-throughput screening methods.

• Establish and evaluate cyclic peptide libraries using microarray formats.
• Screen and optimize cyclic β-catenin binders for improved affinity and specificity.
• Produce prioritized cyclic peptide leads for further studies.
• Utilize automated synthesis and combinatorial array printing to enhance peptide variant screening.
• Collaborate with team members to characterize promising binders biophysically and cellularly.