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Fungal Pathogen Genetics and Engineering Biology● OpenPostdocPreview

Postdoctoral Research Associate in Fungal Pathogen Genetics and Engineering Biology

Develop an AI-driven antifungal drug discovery platform for *Candida auris* using CRISPR screens and single-cell analysis.

Best for:Best for postdoctoral researchers with a PhD in bioengineering, genetics, or synthetic biology, strong hands-on experience in CRISPR, NGS, and bioinformatics, and a passion for translational fungal pathogen research.

Imperial College London · London, United Kingdom · R2 · Recognised researcher
More professors at Imperial College London
CRISPR-based gene predictionSingle-cell sequencingAntifungal drug discoveryYeast geneticsNext-generation sequencing (NGS)Bioinformatics and data analysis
This is a postdoc position — not a PhD studentship.
Deadline
Nov 1, 2026
18 days
Funding
Salaried
£50.7k–£52.7k/yr
Start date
2027-01-01
Full-time
Location
London
United Kingdom

Overview

This postdoctoral position at Imperial College London’s Department of Bioengineering offers a collaborative opportunity to advance antifungal drug discovery for the critical pathogen *Candida auris*. Under the joint supervision of Dr. Sonja Billerbeck and Prof. Rodrigo Ledesma-Amaro, the successful candidate will lead CRISPR-based gene prediction, single-cell sequencing, and tool development within a Wellcome Trust-funded consortium. The interdisciplinary role spans bioinformatics, yeast genetics, and molecular biology, with a focus on scalable bioreactor assays and next-generation sequencing. Applicants should demonstrate expertise in genetic engineering, data analysis, and collaborative research while contributing to high-impact publications and conference presentations. The position emphasizes innovation, interdisciplinary teamwork, and mentorship of undergraduate/postgraduate students.

Postdoctoral Research AssociateFungal pathogen geneticsCRISPR screeningSingle-cell genomicsAntifungal drug discoveryBioinformaticsYeast geneticsNGS

What you'll do

  • Lead CRISPR-based gene prediction and verification through large-scale screens for *Candida auris*.
  • Develop and optimize single-cell sequencing assays to study population heterogeneity in fungal pathogens.
  • Design and execute competitive growth assays in small-scale bioreactors for antifungal drug testing.
  • Collaborate with a multi-PI consortium to integrate findings into an AI-driven antifungal drug discovery platform.
  • Present research at international conferences and publish findings in peer-reviewed journals.
  • Supervise undergraduate and postgraduate research students in laboratory and analytical techniques.
  • Ensure data validity and reliability through rigorous methodological design and statistical analysis.

Requirements

Degree required: PhD in bioengineering, yeast genetics, synthetic biology, natural sciences, biological sciences, or a closely related discipline, or equivalent research/industrial experience.

Language: English (proficiency sufficient for academic research and collaboration)

Instruction: English

Publications: Publication(s) in peer-reviewed journals and project reports to the research sponsor.

Required skills
  • Practical experience in molecular biology (e.g., cloning, genome engineering).
  • Proficiency in bioinformatics and large-scale data analysis, including NGS.
  • Experience with microbiological culturing and assay/tool development.
  • Knowledge of research methods and statistical procedures.
  • Publication record in relevant peer-reviewed journals.
  • Experience collaborating with sponsors and academic partners.
Nice to have
Experience with CRISPR-based screening platforms.Familiarity with AI-driven drug discovery tools.Background in fungal pathogen research or antifungal drug development.
Eligibility
  • No explicit nationality or residency restrictions mentioned.
  • No age or prior experience caps specified.

Funding & terms

Type
Salaried
Amount
£50.7k–£52.7k/yr
Duration
48 months (fixed-term)
Programme
Wellcome Trust-funded initiative
Wellcome Trust

How to apply

Deadline: 2026-11-01

Applicants must submit their CV, cover letter, and research statement through Imperial College London’s job portal. Additional documents may include academic transcripts and contact details for three referees. Ensure all materials are tailored to highlight relevant research experience and alignment with the project goals.

Documents required
  • CV
  • Cover letter
  • Research statement
  • Academic transcripts (if applicable)
  • Three reference letters
↗Apply on site

Contact

SB
Prof.
Sonja Billerbeck
Department of Bioengineering
Lab
Billerbeck and Ledesma-Amaro Labs
Imperial College London
Wellcome Trust-funded initiativeUnited Kingdom
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