PhD in Bio-Based mRNA-Enriched Materials for Bone Regeneration Using AI Optimization
Develop AI-driven bioresorbable scaffolds with mRNA for enhanced bone regeneration through interdisciplinary research.
Best for:Best for biomedical engineers, materials scientists, or biotechnologists with expertise in biomaterials, genetic engineering, and AI-driven computational modeling.
Overview
This PhD position at the University of Toulouse focuses on creating biodegradable scaffolds functionalized with mRNA to promote bone regeneration. The project integrates biomaterials science, genetic engineering, and artificial intelligence to optimize scaffold architecture and mRNA delivery for localized therapeutic protein production. The candidate will work on designing polymer networks, analyzing biological performance, and leveraging AI for computational optimization. The research aims to transform injured cells into localized protein factories, reducing experimental iterations through data-driven design. Collaboration with interdisciplinary teams and contributions to scientific publications are expected.
What you'll do
- Design and synthesize biodegradable polymer scaffolds functionalized with mRNA encoding therapeutic proteins (e.g., VEGF, BMP).
- Investigate the influence of 3D scaffold architecture on osteogenic differentiation and biological performance.
- Develop and apply AI-based computational tools to optimize scaffold composition, architecture, and mRNA loading.
- Conduct in vitro and in vivo experiments to evaluate scaffold efficacy in promoting localized protein production.
- Analyze experimental data using computational methods to guide iterative scaffold design improvements.
- Contribute to scientific publications and present research findings at national and international conferences.
- Collaborate with interdisciplinary teams to integrate biomaterials, genetic engineering, and AI approaches.
Requirements
Degree required: Master's degree (or equivalent) in Biomedical Engineering, Materials Science, Biotechnology, or a related field.
Degree offered: PhD
Language: English proficiency (no specific test score required)
Instruction: French and English
- Experience in biomaterials synthesis and characterization.
- Familiarity with genetic engineering techniques, particularly mRNA delivery systems.
- Knowledge of computational tools for biomaterials design and AI-driven optimization.
- Proficiency in laboratory techniques for cell culture and biological assays.
- Experience with polymer chemistry or materials science.
- Open to international applicants.
- No specific nationality restrictions mentioned.
Funding & terms
How to apply
Deadline: 2026-11-30
Applicants must submit their CV, a cover letter detailing their research interests and motivation, and academic transcripts. A research proposal outlining the candidate’s approach to the project is also required. Applications should be sent via email to the contact provided.
- CV
- Cover letter
- Academic transcripts (BSc and MSc)
- Research proposal (1-2 pages)
- Letter of recommendation (if applicable)
Contact
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