UCD Post-doctoral Researcher Level 1 or 2
Investigate chromatin mechanisms and histone modification dysregulation in disease at University College Dublin.
Best for:Best for postdoctoral researchers with a background in molecular biology, functional genomics, or computational biology seeking chromatin research experience.
Overview
The Chromatin Mechanisms in Disease laboratory at University College Dublin invites applications for a postdoctoral fellow position to study the dysregulation of the repressive histone modification H2AK119ub1 in human diseases. Funded through a Wellcome Trust award and led by Dr. Eric Conway, the project utilizes cancer and neurodevelopmental disease model systems to explore pathogenic variants in PRC1 and PR-DUB complexes. The role offers a hybrid, wet-lab, or computational biology focus, alongside professional development opportunities within the UCD Research Careers Framework. The successful candidate will employ functional genomics, biochemistry, and proteomics techniques to advance understanding of chromatin regulation.
What you'll do
- Investigate how pathogenic variants in PRC1 and PR-DUB complexes contribute to changes in H2AK119ub1 using disease model systems.
- Perform functional genomics, biochemistry, and proteomics methods such as CUT&Tag, RNA-seq, and mass spectrometry.
- Conduct high-throughput pooled CRISPR screens to analyze PR-DUB and PRC1 function.
- Contribute via computational biology, wet-lab experiments, or a hybrid approach depending on expertise.
- Pursue external funding opportunities to support personal career development and group research activities.
- Participate in external training courses, conferences, and professional development programs.
Requirements
Degree required: PhD in a relevant discipline
Language: English; excellent proficiency required.
Instruction: English
- Demonstrated research experience in molecular biology, biochemistry, functional genomics, or computational biology.
- Hands-on expertise with techniques such as RNA-seq, proteomics, or high-throughput screening.
- Ability to work effectively within disease model systems related to cancer or neurodevelopmental disorders.
- For PD1 level: early-stage researchers shortly after completing a PhD or entering a new area, with total postdoctoral experience not exceeding 4 years inclusive of this post.
- For PD2 level: researchers who have completed PD1, with total postdoctoral experience not exceeding 6 years inclusive of this post.
Funding & terms
How to apply
Deadline: 2026-10-19 (Europe/Dublin)
Applications must be submitted online through the Work at UCD portal before the specified closing deadline. Ensure all required documentation is completed and uploaded prior to the system deadline, as late submissions are not accepted.
- CV
Contact
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