PhD Studentship: Decoding and Designing DNA Replication Origins

This interdisciplinary PhD project investigates how DNA replication origins are encoded and regulated within genomes using a combination of computational biology and synthetic biology. Hosted at the Earlham Institute and supported by the Norwich Research Park Biosciences Doctoral Training Partnership, the research involves developing predictive genome language models and testing synthetic DNA sequences in yeast. The successful candidate will work in a collaborative environment across multiple scientific groups to advance the rational design of synthetic chromosomes. Applicants are expected to engage in comprehensive professional training, execute high-throughput experimental and computational workflows, and participate in academic dissemination.

• Develop and apply genome language models to predict and understand replication origin function.
• Design and synthesize hundreds of novel DNA sequences using computational tools.
• Test synthetic sequences in yeast using advanced molecular biology and nanopore sequencing technologies.
• Collaborate across multiple research groups integrating machine learning and high-throughput experimental workflows.
• Complete a three-month professional internship placement during the course of the doctoral study.
• Prepare research findings for publication in peer-reviewed journals and presentation at international conferences.