Postdoctoral Fellow - AI-Enabled Immune Digital Twin & Organ Damage Mechanistic Model
Develop mechanistic and AI-enabled digital twin models linking immune dysfunction to organ damage in critical illness.
Best for:Best for quantitative and computational researchers with expertise in dynamical systems, mechanistic modeling, and biomedical applications.
Overview
The Biocomplexity Institute at Indiana University Bloomington invites applications for a Postdoctoral Fellow position under the direction of Dr. James A. Glazier. The successful candidate will focus on creating interpretable ODE, network, and mechanistic model modules to evaluate organ-damage risk in conditions such as sepsis and critical illness. Responsibilities include mapping clinical biomarkers to model states, formulating biological scoring criteria, and collaborating with national consortium partners. The appointee will also be expected to author technical publications and deliver milestone-ready project outputs. This is a non-tenure-track appointment situated within the Intelligent Systems Engineering department.
What you'll do
- Develop fast, interpretable ODE, network, and mechanistic model modules connecting immune dysfunction to organ injury in vital organs.
- Map clinical time-series data and biomarkers directly to model states.
- Formulate robust biological plausibility metrics and scoring criteria for digital twin ensembles.
- Prepare comprehensive test cases, model packages, and model cards for project validation.
- Collaborate actively with national consortium partners spanning systems biology and clinical data science.
- Draft technical publications, present research findings, and prepare milestone-ready contract deliverables.
Requirements
Degree required: Ph.D. or equivalent terminal degree in a quantitative, computational, or biomedical discipline
Language: English
Instruction: English
- Programming proficiency in Python, Julia, R, or MATLAB
- Demonstrated background in mechanistic modeling, such as ODEs, dynamical systems, QSP, or agent-based modeling
- Familiarity with inflammation, cytokine signaling, sepsis, or critical care biology
- Ability to map clinical biomarkers to computational model states
Funding & terms
How to apply
Deadline: 2026-11-07
Interested candidates should submit their application materials through the external application portal or reach out directly to Professor James Glazier via email with any position-related questions.
- CV
Contact
James Glazier· Professor / Principal Investigator
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