PhD Position in Traumatic Brain Injury Research

This PhD position at the Netherlands Institute for Neuroscience (NIN) in Amsterdam focuses on understanding how repeated mild traumatic brain injuries (TBI) lead to long-term memory problems and dementia risk. Led by Dr. Evgenia Salta, the project combines transcriptomics, single-nucleus RNA sequencing, and human postmortem brain tissue analysis to dissect inflammatory and neurogenic alterations in the hippocampus. The research aims to identify cellular targets for future therapies, bridging gaps between TBI, Alzheimer’s, and other dementias. The candidate will work collaboratively with Carlos Fitzsimons at the University of Amsterdam, leveraging advanced computational and cell culture techniques.

• Conduct single-nucleus RNA sequencing to analyze postmortem human brain tissue from TBI donors, focusing on hippocampal alterations.
• Develop and apply advanced computational pipelines to identify cellular and molecular programs linked to injury-induced memory decline.
• Establish in vitro human cell models to investigate causal relationships between candidate targets and cellular phenotypes.
• Collaborate with Carlos Fitzsimons’ group at the University of Amsterdam to integrate findings across neuroscience and life sciences.
• Present research progress at internal lab meetings and external conferences, and contribute to peer-reviewed publications.
• Maintain meticulous documentation of experimental procedures, data analysis, and results for reproducibility.