PhD Position on Molecular Interactions in the Mammalian Circadian Clock
Investigate structural and molecular mechanisms of PERIOD protein interactions within the mammalian circadian clock.
Best for:Best for life science graduates with a strong foundation in protein biochemistry, biophysics, and structural biology techniques.
Overview
The International PhD Programme (IPP) Mainz invites applications for a fully funded PhD position at the Institute of Molecular Biology in the research group of Eva Wolf. The successful candidate will focus on 3D structural and molecular mechanistic analyses of PERIOD protein complexes using in vitro biochemistry, structural biology, and biophysical methods. The work involves investigating how PER1 and associated complexes impact the primary and secondary feedback loops of the circadian clock. Applicants are expected to hold a relevant master's degree and bring a strong background in protein biochemistry and structural analysis.
What you'll do
- Characterize protein interactions of PERIOD clock complexes using in vitro biochemistry and biophysical assays
- Determine high-resolution 3D structures of protein complexes using X-ray crystallography or Cryo-EM
- Investigate the molecular mechanistic role of PER1, WDR5, and nuclear receptor interactions in circadian feedback loops
- Perform quantitative protein interaction and spectroscopy studies
- Collaborate within an interdisciplinary international research environment and participate in advanced training activities
Requirements
Degree required: Master Degree or equivalent
Degree offered: PhD
Language: English; good command required
- Previous theoretical and practical exposure to 3D-structural analysis of proteins
- Hands-on experience in biochemical and biophysical protein analyses
- Practical experience with relevant protein complex techniques
- Good command of the English language
Funding & terms
How to apply
Deadline: 2026-10-15 (Europe/Berlin)
Interested candidates should submit their application through the online IPP application platform and select Wolf as their group preference. Applicants must also arrange for two letters of reference to be submitted.
- CV
- 2 letters of reference
- Master Degree certificate or equivalent
Contact
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