PhD Studentship: Mutant Blood Stem Cells and Bone Marrow Ageing
Investigate how mutant blood stem cells reshape their microenvironment to drive accelerated ageing.
Best for:Best for bioscience graduates with a strong interest in stem cell biology, cellular metabolism, and ageing.
Overview
This 4-year PhD studentship at the University of East Anglia's Norwich Medical School explores how mutant blood stem cells outgrow normal counterparts and actively alter the bone marrow niche. The successful candidate will investigate cellular, genetic, and metabolic mechanisms underlying accelerated blood cell ageing. Working within the Mistry and Rushworth Lab alongside the Earlham Institute, the student will employ advanced techniques including flow cytometry, in-vivo modelling, and RNA-sequencing. Candidates will benefit from a comprehensive training environment featuring specialist workshops, journal clubs, and presentation opportunities across the Norwich Research Park.
What you'll do
- Design and execute flow cytometry experiments across the complete blood hierarchy.
- Conduct tissue culture and in-vivo modelling investigations.
- Perform gene expression profiling using RNA-sequencing methodologies.
- Execute metabolic assays to evaluate cellular changes.
- Participate actively in regular laboratory meetings, collaborative discussions, and journal clubs.
- Present research findings at regional, national, and international scientific meetings.
Requirements
Degree required: BSc or MSc in molecular biology, cell biology, immunology, genetics, or related bioscience discipline
Degree offered: PhD
Language: English
Instruction: English
- Background in molecular or cell biology, immunology, genetics, or related bioscience discipline
- Demonstrated interest in stem cell biology or cellular ageing
- Capability to perform multidisciplinary laboratory research
- Open to applicants meeting the criteria of the Norwich Research Park Biosciences Doctoral Training Partnership
Funding & terms
How to apply
Deadline: 2026-11-30
Applicants should visit the official university course page via the apply button to review full entry instructions and submit their application documentation online before the closing date.
- CV
- Cover letter
- Transcripts
Create a free profile to unlock your personal match score, the full requirements, funding details and how to apply — in English or Persian.