Postdoctoral Research Associate in Cardiovascular Genetics
Join a world-leading cardiovascular research team to investigate novel genes for Brugada syndrome using zebrafish models.
Best for:Best for postdoctoral researchers with a PhD in molecular biology, cellular biology, or biochemistry and hands-on experience in CRISPR, zebrafish disease modelling, and functional genomics.
Overview
This postdoctoral position at City, University of London’s Cardiovascular Research Institute focuses on characterising and validating novel genes linked to Brugada syndrome—a leading cause of sudden cardiac death in young people—using zebrafish as a disease model. The project, funded by the Academy of Medical Sciences and British Heart Foundation, involves designing CRISPR-mediated gene knockdowns, functional analyses, and protocol optimisation. The role is ideal for researchers with expertise in molecular biology, gene editing, and zebrafish husbandry, offering autonomy in experimental design and data interpretation. The 18-month fixed-term position is based in London and requires limited supervision, making it suitable for independent yet collaborative postdocs.
What you'll do
- Design and execute CRISPR-mediated gene knockdowns of zebrafish orthologues for novel Brugada syndrome genes.
- Conduct functional analyses to assess the impact of gene knockdowns on heart function and arrhythmia phenotypes.
- Develop and optimise new experimental techniques and protocols critical to the project.
- Provide technical expertise and troubleshoot experiments independently with limited supervision.
- Contribute to data analysis, interpretation, and presentation of research findings.
- Collaborate with a multidisciplinary team to advance understanding of genetic mechanisms in cardiac diseases.
Requirements
Degree required: PhD in molecular biology, cellular biology, biochemistry, or a related discipline
Language: English; proficiency sufficient for academic research and collaboration
Instruction: English
- Practical expertise in CRISPR-mediated gene editing techniques
- Extensive experience in zebrafish husbandry and disease model development
- Proven ability to design and execute functional assays for gene mutation effects
- Strong problem-solving skills and technical proficiency in molecular biology
- Experience working in a multi-disciplinary research environment
- No specific nationality or residency restrictions mentioned
- Open to applicants with prior postdoctoral experience preferred but not strictly required
Funding & terms
How to apply
Deadline: 2026-10-25
Applicants must submit their CV, cover letter, and a 7-minute presentation highlighting relevant research experience and impact through the university’s job portal. Interviews will follow, with dates to be confirmed later.
- CV
- Cover letter
- 7-minute presentation on relevant research experience and impact
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