PhD in Structural and Functional Characterization of a Novel Non-Specific Lipase in Hazelnut
Explore the biochemical mechanisms of hazelnut rancidity through advanced crystallography and biophysical techniques in a multidisciplinary international collaboration.
Best for:Best for candidates with a strong background in structural biology, protein biochemistry, or related fields, eager to contribute to interdisciplinary research at the intersection of chemistry and food science.
Overview
This PhD position offers the opportunity to investigate the structural and functional properties of a newly identified non-specific lipase in hazelnut seeds, contributing to understanding the biochemical mechanisms behind hazelnut rancidity. The project involves collaboration between the time-resolved serial crystallography team at ESRF’s ID29 beamline, the University of Turin’s Department of Science and Pharmaceutical Technology, and Soremartec (Ferrero). Using a combination of biophysical, biochemical, and time-resolved crystallography techniques, the research aims to elucidate the molecular mechanisms driving rancidity. The successful candidate will be enrolled in the University of Turin’s doctoral programme and conduct research at the ESRF in Grenoble, France.
What you'll do
- Conduct structural and functional characterization of a novel non-specific lipase identified in hazelnut seeds using advanced biophysical and biochemical techniques.
- Apply time-resolved serial crystallography to study the biochemical mechanisms underlying hazelnut rancidity.
- Collaborate with researchers from ESRF, University of Turin, and Soremartec to integrate findings across disciplines.
- Develop and optimize experimental protocols for protein crystallization and structural analysis.
- Present research findings at scientific conferences and publish results in peer-reviewed journals.
- Participate in the Nextstep Doctoral Programme, contributing to broader research on sustainable development and industrial competitiveness.
Requirements
Degree required: Master’s degree (or equivalent, such as MSc, Master 2 de Recherche, Laurea) in chemistry, materials science, physics, or a closely related field
Degree offered: PhD
Language: English proficiency at upper-intermediate (B2) level; proof required unless applicant is from a native-English-speaking country or holds an English-taught degree
Instruction: English
- Background in structural biology or protein biochemistry (desirable but not mandatory)
- Proficiency in biophysical and biochemical techniques
- Experience with protein crystallization and structural analysis
- Strong analytical and problem-solving skills
- Ability to work collaboratively in an international research environment
- Must not already be enrolled in or possess a doctoral degree at the time of recruitment
- Must satisfy conditions for enrolment in a doctoral programme at the University of Turin
- Must comply with the Marie Skłodowska-Curie mobility rule: no more than 12 months of residence or activity in France within the last three years prior to the application deadline
- Must provide proof of diploma completion at the time of application (official certificate acceptable if diploma not yet issued)
Funding & terms
How to apply
Deadline: 2027-07-24 (Europe/Paris)
Applicants must submit their application through the external portal linked in the job description. Required documents include a CV, proof of English proficiency (B2 level), proof of diploma completion, and any additional materials specified in the application guidelines. The application process involves a review of qualifications and research fit for the project.
- CV
- Proof of upper-intermediate English proficiency (B2 level or equivalent)
- Proof of diploma completion (or official certificate if diploma not yet issued)
- Cover letter or research statement (if required)
- Reference letters (if required)
Contact
Daniele de Sanctis / Salvatore Adinolfi· Supervisors
daniele.de_sanctis@esrf.fr / Salvatore.adinolfi@unito.it
+33 (0)4 76 88 28 69 / +39 (0)1 16 70 68 62
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