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Post-Doctoral Research Associate in Epigenetics and Gene Regulation

Investigate non-canonical transcription regulation through DNA methylation using functional genomics and human stem cell models.

Best for:Best for molecular biologists and computational researchers with strong expertise in epigenomics, functional genomics assays, or stem cell models.

The University of Edinburgh · Edinburgh, United Kingdom · R2 · Recognised researcher
More professors at The University of Edinburgh
EpigeneticsGene RegulationDNA MethylationFunctional GenomicsStem Cell Biology
This is a postdoc position — not a PhD studentship.
Deadline
Oct 14, 2026
Expired
Funding
Salaried
£41.1k–£48.8k/yr
Start date
2027-01-01
Full-time
Location
Edinburgh
United Kingdom

Overview

The University of Edinburgh's Institute of Genetics and Cancer is seeking a motivated postdoctoral research associate to join Dr Duncan Sproul's laboratory. This fixed-term position focuses on understanding how DNA methylation within gene bodies regulates transcription using functional genomics assays and synthetic approaches. Working closely within an interdisciplinary team alongside collaborating groups in Edinburgh and Exeter, the successful candidate will conduct advanced sequencing assays and human embryonic stem cell experiments. The role offers an opportunity to drive impactful research toward high-profile publications in the fields of epigenomics and gene regulation.

EpigenomicsDNA MethylationTT-seqCUT&RUNNanopore SequencingStem CellsMolecular BiologyTranscription Regulation

What you'll do

  • Design and execute functional genomics assays such as TT-seq, CUT&RUN, and Nanopore sequencing.
  • Utilize human embryonic stem cell models and synthetic landing-pad approaches to study transcriptional regulation.
  • Analyze complex sequencing and molecular biology data using computational data analysis approaches.
  • Collaborate closely with multidisciplinary teams across the Universities of Edinburgh and Exeter.
  • Contribute to drafting manuscripts and driving research projects toward publication in peer-reviewed scientific journals.
  • Present research findings at group meetings, collaborative workshops, and scientific conferences.

Requirements

Degree required: PhD in a relevant discipline (or soon to be awarded)

Language: English; professional working proficiency

Instruction: English

Publications: Track record or ability to drive research projects toward publication

Required skills
  • Demonstrated experience in molecular biology, cellular biology, biochemistry, or computational data analysis
  • Ability to think independently and work effectively within an interdisciplinary team
  • Hands-on experience with genomic or cellular techniques relevant to gene regulation
Nice to have
Strong publication track record or demonstrated research experience in epigenomicsExtensive experience working with human stem cell modelsSpecialised expertise in functional genomics assays such as TT-seq, CUT&RUN, or Nanopore sequencing
Eligibility
  • Must have been awarded, or be soon to be awarded, a PhD in a relevant discipline

Funding & terms

Type
Salaried
Amount
£41.1k–£48.8k/yr
Duration
30 months
Programme
The University of Edinburgh
The University of Edinburgh

How to apply

Deadline: 2026-10-14

Interested candidates should submit their application online through the university's candidate experience portal by the specified deadline. Ensure all required documentation including academic credentials and application forms are uploaded correctly.

Documents required
  • CV
  • Cover letter
↗Apply on site

Contact

DS
Prof.
Duncan Sproul
Institute of Genetics and Cancer
Lab
Sproul Group
The University of Edinburgh
United Kingdom
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