PhD Position in Neuronal Hyperactivity and Maladaptive Myelination in Alzheimer’s Disease
Investigate the link between neuronal hyperexcitability, microglia, and aberrant myelination in early-stage Alzheimer's disease.
Best for:Best for candidates with a strong background in neuroscience, animal models, and an interest in neurodegeneration.
Overview
The University of the Basque Country (UPV/EHU) is offering a PhD position focused on the mechanisms of circuit dysfunction in early Alzheimer's disease. The research project, titled HyperMyel-AD, explores how neuronal hyperactivity in the hippocampus influences microglia and subsequent oligodendrocyte maturation. The successful candidate will utilize 3xTg-AD mouse models to examine how these cellular interactions contribute to network instability and cognitive decline. The work aims to identify novel therapeutic targets by testing whether modulating hyperactivity-dependent myelination can mitigate disease progression.
What you'll do
- Conduct experimental research using 3xTg-AD mouse models to study hippocampal CA1 hyperexcitability.
- Analyze the impact of neuronal hyperactivity on microglia and oligodendrogenesis.
- Investigate the relationship between white matter damage and cognitive or behavioral deficits.
- Evaluate potential therapeutic strategies targeting hyperactivity-dependent myelination.
- Document research findings and contribute to scientific publications and project reports.
Requirements
Degree required: Master's degree or equivalent in Neuroscience, Biology, or a related field.
Degree offered: PhD
Language: English proficiency required for research and reporting.
Instruction: English/Spanish
- Experience with animal models in neuroscience research.
- Proficiency in histological or molecular techniques related to neurobiology.
- Strong analytical skills for interpreting complex biological data.
- Must hold a Master's degree or equivalent at the time of appointment.
Funding & terms
How to apply
Deadline: 2026-11-05 (Europe/Madrid)
Interested candidates should submit their application through the official university portal provided in the job link. Ensure all required academic documentation is prepared according to the university's specific guidelines for PhD applicants.
- CV
- Academic transcripts
- Cover letter
Contact
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