Enhancing STING Signaling via UBE2N Inhibition: Dual Effects on Activation and Stability
Explore the dual role of UBE2N inhibition in modulating STING signaling pathways for potential therapeutic applications.
Best for:Best for PhD candidates with expertise in molecular biology, immunology, or biochemistry seeking to contribute to translational research with potential clinical implications.
Overview
This PhD position at Université de Caen Normandie focuses on investigating how inhibiting UBE2N can simultaneously enhance and stabilize STING signaling pathways. STING (Stimulator of Interferon Genes) plays a critical role in immune responses, and understanding its regulation could open new avenues for treating autoimmune diseases, infections, and cancers. The project combines molecular biology, biochemistry, and cellular assays to dissect the mechanistic underpinnings of UBE2N’s influence on STING. Applicants should have a strong background in molecular biology or related fields and a keen interest in immunology or disease mechanisms.
What you'll do
- Conduct molecular and biochemical experiments to investigate the effects of UBE2N inhibition on STING signaling pathways.
- Develop and validate assays to measure STING activation and stability under experimental conditions.
- Analyze cellular responses to UBE2N modulation using advanced imaging and biochemical techniques.
- Collaborate with research teams to interpret experimental data and propose mechanistic hypotheses.
- Present research findings at national and international conferences and publish results in peer-reviewed journals.
- Maintain detailed laboratory records and ensure compliance with ethical and safety protocols.
Requirements
Degree required: Master's degree (or equivalent) in Molecular Biology, Biochemistry, Immunology, or a related field
Degree offered: PhD
Language: English proficiency (no specific test score mentioned); French is preferred for laboratory communication
Instruction: French (primary) and English (secondary)
- Proven experience in molecular biology techniques (e.g., PCR, cloning, Western blotting)
- Familiarity with cell culture and transfection methods
- Proficiency in biochemical assays and protein analysis
- Experience with data analysis and statistical methods
- Open to international applicants
- No specific residency or nationality restrictions mentioned
- No age or prior experience caps specified
Funding & terms
How to apply
Deadline: 2026-10-30
Applicants must submit their application through the Campus France portal. The application should include a CV, a cover letter detailing research interests and motivation, academic transcripts, and a research proposal outlining the intended approach to the project. Two reference letters are also required.
- CV
- Cover letter
- Academic transcripts (BSc and MSc)
- Research proposal
- Two reference letters
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