Mapping and Regulation of Allele-Specific Genes During Piglet Development

This 6-month research internship is offered by the Regulatory Genomics for Animal Species (REGLISS) team at the GenPhySE laboratory of INRAE in France. The successful candidate will analyze large-scale RNA-seq and genomic datasets derived from embryonic stem cells and placental tissues of reciprocal pig crosses. The project aims to identify genes exhibiting monoallelic or allele-specific expression, characterize parental imprinting dynamics across gestation stages, and map associated biological functions. Applicants will utilize high-performance computing clusters and R to build reproducible analysis pipelines.

• Process and analyze RNA-seq datasets from embryonic stem cells and placental tissues
• Identify genetic variants and SNPs within transcripts to determine parental origin of gene expression
• Distinguish between allele-specific expression and parent-specific monoallelic expression
• Examine gene expression variations across multiple tissues and gestation stages
• Characterize gene networks and associated biological functions related to allele-specific regulation
• Develop reusable and interoperable computational analysis pipelines