Scientist/Senior Scientist in Cell, Molecular & Chemical Biology
Join the Taosheng Chen Lab at St. Jude Children’s Research Hospital to advance chemical probe development for nuclear receptors PXR and CAR.
Best for:Best for experienced researchers in cell/molecular/chemical biology with a track record of high-impact publications and interdisciplinary collaboration skills.
Overview
This position at St. Jude Children’s Research Hospital offers a Scientist or Senior Scientist role within the Taosheng Chen Lab, focusing on cell, molecular, and chemical biology. The successful candidate will lead research to develop and characterize novel chemical probes targeting nuclear receptors PXR and CAR, integrating multidisciplinary approaches including structural biology and medicinal chemistry. The role involves independent experimental design, high-quality data generation, and collaborative manuscript writing. The lab’s work aims to elucidate nuclear receptor-driven transcriptional networks and develop innovative therapeutic strategies for drug resistance and tumorigenesis. The position is ideal for researchers with a strong publication record and expertise in chemical biology, molecular biology, and related fields.
What you'll do
- Design and execute independent research projects to develop and characterize novel chemical probes targeting nuclear receptors PXR and CAR.
- Generate high-quality datasets to test scientific hypotheses and integrate findings across cell biology, molecular biology, and chemical biology disciplines.
- Collaborate closely with structural biologists and medicinal chemists to generate complementary data and advance multidisciplinary projects.
- Lead the organization and writing of multidisciplinary manuscripts, ensuring high-impact publication outcomes.
- Develop new research protocols, techniques, and procedures to advance the lab’s research goals.
- Interpret experimental data, ensure data integrity, and present research findings to colleagues or at external meetings.
- Train and oversee laboratory staff in techniques and procedures, and provide input on lab operations and equipment maintenance.
- Maintain regular attendance and meet departmental and institutional goals.
Requirements
Degree required: PhD in cell biology, molecular biology, chemical biology, pharmacology, or a related field (with productive postdoctoral research experience preferred). Bachelor’s degree is the minimum requirement but not sufficient for the role.
Language: English (proficiency required for communication and publication).
Instruction: English
Publications: Strong track record of impactful publications, particularly in high-quality journals.
- Expertise in cell and molecular biology with exposure to chemical biology.
- Experience evaluating small-molecule mechanisms of action.
- Basic understanding of structural biology and ligand-protein interactions.
- Basic understanding of medicinal chemistry and structure-activity relationships.
- Experience with cloning, plasmid construction, RNA isolation, gene expression analysis, and transcriptional profiling.
- Experience with protein-compound interactions, protein-protein interactions, and proteomic profiling.
- Experience with murine studies (a plus).
- For Scientist role: 3 years of relevant experience with a PhD, 6 years with a Master’s, or 8 years with a Bachelor’s.
- For Senior Scientist role: 5 years of relevant experience with a PhD, 8 years with a Master’s, or 10 years with a Bachelor’s.
Funding & terms
How to apply
Deadline: 2026-11-17
Applicants should submit their CV, cover letter, and a list of publications to the recruitment contact. Additional documents may be requested based on the application. The application process involves human review and engagement, ensuring a human-centered experience.
- CV
- Cover letter
- List of publications
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