Scientist II, TCR Discovery Team

Weill Cornell Medicine is seeking a Scientist II to join the TCR Discovery Team within MCC Laboratories on the Upper East Side. The successful candidate will drive the development of personalized TCR-based cell therapies targeting autologous tumors through rigorous, high-throughput discovery and preclinical development. Responsibilities include leading end-to-end TCR identification, cloning, specificity validation, and safety de-risking for clinical applications. Applicants are expected to work collaboratively in a multidisciplinary environment, mentor junior staff, and generate robust preclinical data packages.

• Contribute hands-on to end-to-end personalized TCR discovery including tumor-reactive T cell identification, cloning, characterization, and safety de-risking.
• Utilize advanced de-risking workflows such as X-scan, peptide library screens, and library-on-library HTS to assess alloreactivity and toxicity risks.
• Analyze and interpret complex screening campaigns to identify TCRs against known tumor antigens.
• Generate comprehensive data packages covering functional potency, specificity, and safety to support clinical candidate selection.
• Support the design and execution of preclinical IND-enabling studies.
• Maintain detailed records of experiments, perform data analysis, and prepare technical reports.
• Collaborate cross-functionally with vector development and T cell translation teams.
• Mentor and train junior scientists and staff to promote scientific rigor and career advancement.
• Prepare scientific abstracts, research articles for publication, and conference presentations.