Research Associate - Kidney and Cardiovascular Disease Research

The Division of Renal-Electrolyte and Hypertension in the Department of Medicine at the Perelman School of Medicine, University of Pennsylvania, invites applications for a Research Associate position. The appointee will engage in collaborative biomedical research focusing on the molecular and cellular mechanisms of kidney and cardiovascular-metabolic diseases, with an emphasis on diabetic kidney disease and SGLT2 inhibitors. Responsibilities include designing and executing molecular biology experiments, utilizing genetically modified mouse models, and analyzing complex multi-omics and spatial transcriptomic datasets. The initial appointment is for one year with potential renewal up to three years based on performance and funding availability. Candidates must hold an M.D., M.D./Ph.D., or equivalent degree and possess strong expertise in molecular biology, genomics, or a related biomedical field.

• Design and conduct biomedical research focusing on molecular and cellular mechanisms of kidney and cardiovascular-metabolic diseases.
• Perform advanced molecular and cellular experiments, including gene expression analysis, plasmid construction, and primary cell culture.
• Utilize genetically modified mouse models to investigate disease mechanisms and therapeutic responses to SGLT2 inhibitors.
• Perform computational analyses on human genetic, single-cell/single-nucleus RNA sequencing, and spatial transcriptomic datasets.
• Integrate multi-omics data to identify disease-associated cellular states, molecular pathways, and therapeutic targets.
• Conduct functional validation studies and interpret experimental findings to contribute to scientific discoveries.
• Collaborate with multidisciplinary research teams and specialized research facilities.