PhD Position in Microfluidic Blood-Brain Barrier Monitoring Systems
Develop a microfluidic blood-brain barrier model with real-time optical and electrical monitoring.
Best for:Best for biology or engineering graduates with a strong interest in microfluidics, biosensors, and cell co-cultures.
Overview
This doctoral position at Université Paris-Saclay focuses on designing and evaluating an advanced microfluidic chip simulating the blood-brain barrier (BBB). Working within the Laboratory of Materials for Sensors and Delivery (LETI) under the supervision of Yohann Thomas, the candidate will integrate optical and electrical measurement systems for real-time monitoring. The project combines microtechnologies, cellular co-cultures, and integrated sensors to study permeability, transendothelial resistance, and pharmacological responses. The successful applicant will contribute to creating novel predictive tools for neuropharmacology, toxicology, and neurodegenerative disease research.
What you'll do
- Design and fabricate microfluidic chips representing the blood-brain barrier model
- Implement simultaneous optical and real-time electrical measurement systems
- Perform cell co-cultures and maintain biological models within microdevices
- Evaluate cellular responses, permeability, and transendothelial resistance under various pharmacological stimuli
- Analyze experimental data and compare in vitro findings with conventional systems
- Contribute to scientific publications and present research findings at conferences
Requirements
Degree required: Master's degree or equivalent in a relevant scientific or engineering discipline
Degree offered: PhD
Language: English or French proficiency as appropriate for research and publication
Instruction: French / English
- Background in cell biology, microfluidics, or biomedical engineering
- Experience with in vitro cell culture techniques
- Ability to analyze experimental biological and physical data
- Strong written and verbal communication skills
Funding & terms
How to apply
Deadline: 2026-11-30
Submit your application through the official platform by providing the required academic documents and contacting the supervisor if necessary.
- CV
- Cover letter
- Academic transcripts
Contact
Yohann Thomas· Supervisor
04.38.78.39.89
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