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Physiology and Proteomics● OpenResearch staffPreview

Research Associate in Department of Physiology

Conduct advanced mass spectrometry-based proteomics and structural biology research at the University of Pennsylvania.

Best for:Best for experienced proteomics researchers with a strong background in mass spectrometry, protein biochemistry, and molecular biology.

University of Pennsylvania · Philadelphia, United States · R2 · Recognised researcher
More professors at University of Pennsylvania
proteomicsmass spectrometrystructural biologymitochondrial biologychemical biology
This is a research staff position — not a PhD studentship.
Deadline
Jun 2, 2028
597 days
Funding
—
Initial appointment for 1 year, renewable up to 3 years total based on performance and funding
Start date
Jun 02, 2026
Full-time
Location
Philadelphia
United States

Overview

The Department of Physiology at the Perelman School of Medicine, University of Pennsylvania, seeks a Research Associate to join its academic support staff. The appointee will spearhead research in mass spectrometry-based proteomics, structural proteomics, and mitochondrial biology while operating advanced LC-MS/MS instrumentation. Responsibilities include designing and executing independent and collaborative research workflows, managing complex datasets, and mentoring junior trainees. Candidates will also have opportunities to contribute to grant writing, manuscript preparation, and interdisciplinary scientific initiatives.

Research AssociateLC-MS/MSproteomicsstructural proteomicsmass spectrometryprotein biochemistrymolecular biologyUniversity of Pennsylvania

What you'll do

  • Conduct independent and collaborative research in structural proteomics, chemical biology, and mitochondrial biology.
  • Develop and implement mass spectrometry-based workflows, including chemical crosslinking mass spectrometry (XL-MS), quantitative proteomics, and protein interaction mapping.
  • Operate, maintain, and troubleshoot advanced LC-MS/MS instrumentation and Orbitrap platforms.
  • Analyze complex proteomics datasets using advanced software tools.
  • Mentor students and junior research trainees.
  • Contribute to manuscript preparation, grant writing, and collaborative research initiatives.

Requirements

Degree required: Ph.D. or M.D./Ph.D. degree

Language: English

Instruction: English

Publications: A strong record of original peer-reviewed publications

Required skills
  • Expertise in mass spectrometry-based proteomics, including LC-MS/MS instrumentation, experimental design, and data analysis.
  • Strong background in protein biochemistry, molecular biology, and quantitative proteomics approaches.
  • Demonstrated experience designing and executing independent research projects within multidisciplinary teams.
  • Hands-on experience with Orbitrap-based mass spectrometry platforms and quantitative proteomics workflows.
Nice to have
Expertise in chemical crosslinking mass spectrometry (XL-MS), structural proteomics, and protein interaction mapping.Experience with the development of novel analytical methodologies and computational analysis of proteomics datasets.Familiarity with mitochondrial biology, neuroscience, reproductive biology, cryo-EM, or integrative structural biology.

Funding & terms

Type
Unknown
Amount
—
Duration
Initial appointment for 1 year, renewable up to 3 years total based on performance and funding
Programme
University of Pennsylvania
University of Pennsylvania

How to apply

Deadline: 2028-06-02 (America/New_York)

Interested candidates should submit their application materials online through the provided Interfolio portal link. Ensure all required documentation and background qualifications are addressed prior to the deadline.

Documents required
  • CV
↗Apply via form
Lab
Department of Physiology, Perelman School of Medicine
University of Pennsylvania
United States
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