PhD Position in Human Neural Stem Cell Lineages

The Baffet Lab at the Institut Curie is seeking a motivated PhD student to study the mechanisms of human neocortex development. This project focuses on understanding how radial glial cells generate neuronal and glial diversity across different cortical regions. The successful candidate will utilize human fetal tissue and regionalized cortical organoids, employing a live/fixed correlative imaging pipeline and Live-seq technology. The research aims to map spatiotemporal neural stem cell lineages and identify the molecular determinants of fate specification. This position offers an opportunity to contribute to cutting-edge developmental biology research within an ERC-funded project.

• Conduct research on human neural stem cell lineages using fetal tissue and cortical organoids.
• Perform live/fixed correlative imaging to observe radial glial cell divisions.
• Quantify proliferative, neurogenic, and gliogenic division modes across space and time.
• Integrate single-cell transcriptomics with lineage analysis to identify molecular signatures of fate decisions.
• Collaborate with team members to maintain and develop imaging pipelines.
• Communicate research findings through presentations and scientific publications.