PhD in Modulating X Chromosome Gene Dosage and Senescence Induction
Explore the mechanisms of X chromosome gene dosage and cellular senescence in a multidisciplinary PhD project at CBI, Toulouse.
Best for:Best for motivated biological sciences graduates with a strong background in molecular biology, genomics, or related fields, seeking interdisciplinary research in cellular senescence and gene regulation.
Overview
This PhD position is part of the BEST Doctoral Programme at the University of Toulouse and will be conducted at the Centre for Integrative Biology (CBI) in Toulouse, France. The project focuses on investigating how modulation of X chromosome gene dosage influences cellular senescence, a key process in aging and disease. Under the supervision of Estelle Nicolas, the candidate will leverage advanced techniques in molecular biology, genomics, bioengineering, and bioinformatics. The project includes a 6-month international collaboration with the Stem Cell Epigenetics Lab in Lisbon, Portugal, where the candidate will gain expertise in human embryonic stem cell manipulation. The CBI, affiliated with CNRS and the University of Toulouse, provides a dynamic environment for interdisciplinary research spanning molecular to organismal scales.
What you'll do
- Conduct research on the modulation of X chromosome gene dosage and its impact on cellular senescence using advanced molecular biology techniques.
- Perform experiments involving cell culture, genomics, bioengineering, and bioinformatics to analyze gene expression and epigenetic modifications.
- Collaborate with the Stem Cell Epigenetics Lab in Lisbon, Portugal, for a 6-month training period on genetic manipulation of human embryonic stem cells.
- Transfer acquired knowledge and techniques back to the CBI lab in Toulouse for continued research.
- Present research findings at conferences and publish results in peer-reviewed journals.
- Contribute to the development of interdisciplinary research approaches combining molecular, cellular, and systems biology.
Requirements
Degree required: Master's degree or equivalent in Biological Sciences, Molecular Biology, Genetics, or a related field
Degree offered: PhD
Language: English; proficiency sufficient for academic research and collaboration
Instruction: English
- Proven expertise in molecular biology techniques, including cell culture and gene manipulation.
- Experience with genomics and bioinformatics tools for data analysis.
- Familiarity with microscopy and related imaging techniques.
- Strong background in molecular and cellular biology research.
- Applicants must meet the eligibility criteria for the BEST Doctoral Programme of the University of Toulouse.
- No specific nationality restrictions, but compliance with EU funding regulations may apply.
Funding & terms
How to apply
Deadline: 2026-10-23 (UTC)
Applicants must apply through the BEST Doctoral Programme portal. Ensure you meet all eligibility criteria before submitting your application. The application process includes submitting academic transcripts, a research proposal, and letters of recommendation. Detailed instructions and required documents are available on the CBI website.
- Curriculum Vitae (CV)
- Academic transcripts (Bachelor’s and Master’s degrees)
- Research proposal or statement of purpose
- Two letters of recommendation
- Proof of English proficiency if applicable
Contact
Centre for Integrative Biology (CBI)· PhD Programme Coordinator
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